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1. (WO2018055031) ACID-BASE TRANSPORT INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/055031 International Application No.: PCT/EP2017/073896
Publication Date: 29.03.2018 International Filing Date: 21.09.2017
IPC:
G01N 33/50 (2006.01) ,G01N 33/48 (2006.01) ,G01N 33/574 (2006.01)
Applicants: AARHUS UNIVERSITET[DK/DK]; Nordre Ringgade 1 8000 Aarhus C, DK
Inventors: BØDTKJER, Briggs, Ebbe; DK
TOFT, Memborg, Nicolai; DK
Agent: HØIBERG P/S; Adelgade 12 1304 Copenhagen K, DK
Priority Data:
PA 2016 7074621.09.2016DK
Title (EN) ACID-BASE TRANSPORT INHIBITORS
(FR) INHIBITEURS DE TRANSPORT ACIDOBASIQUE
Abstract: front page image
(EN) Methods and uses are provided for diagnosing, prognosing and treating breast cancer by determining the determining the Na+/HCO3co-transport activity and/or Na+/H+ exchange activity in cells of a sample from a patient, and establishing the relative importance of Na+/HCO3co-transport and/or Na+/H+ exchange for intracellular pH regulation, and by comparing a predetermined value determining the diagnosing, prognosing and treatment.
(FR) La présente invention concerne des procédés et des utilisations pour diagnostiquer, pronostiquer et traiter le cancer du sein par détermination de l'activité de co-transport de Na+/HCO3 et/ou l’activité d’échange Na+/H+ dans des cellules d’un échantillon d'un patient, et la détermination de l'importance relative du co-transport de Na+/HCO3 co-transport et/ou l’échange Na+/H+ pour la régulation du pH intracellulaire et comparaison d’une valeur prédéterminée déterminant le diagnostic, le pronostic et le traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)