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Pub. No.:    WO/2018/055016    International Application No.:    PCT/EP2017/073858
Publication Date: 29.03.2018 International Filing Date: 21.09.2017
C07F 9/6558 (2006.01), A61K 31/675 (2006.01), A61P 9/00 (2006.01)
Applicants: IDORSIA PHARMACEUTICALS LTD [CH/CH]; Hegenheimermattweg 91 4123 Allschwil (CH)
Inventors: LEUENBERGER, Daniel; (CH).
REBER, Stefan; (CH).
VON RAUMER, Markus; (CH)
Agent: KOBERSTEIN, Ralf; (CH)
Priority Data:
PCT/EP2016/072562 22.09.2016 EP
Abstract: front page image
(EN)The invention relates to crystalline forms of 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride, processes for the preparation thereof, pharmaceutical compositions comprising said crystalline forms, pharmaceutical compositions prepared from such crystalline forms and their use as a medicament, especially as a P2Y12 receptor antagonist.
(FR)L'invention concerne des formes cristallines de chlorhydrate d'ester butylique 4- ( R )-2-{[6- (( S )-3-méthoxy-pyrrolidin-1-yl)-2-phényl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-pipérazine-1-carboxylique, des procédés pour leur préparation, des compositions pharmaceutiques comprenant lesdites formes cristallines, des compositions pharmaceutiques préparées à partir de telles formes cristallines et leur utilisation en tant que médicament, en particulier en tant qu'antagoniste du récepteur P2Y 12 .
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)