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1. (WO2018054354) APPLICATION OF SRC HOMOLOGY REGION 2-CONTAINING PROTEIN TYROSINE PHOSPHATASE-1 AGONIST FOR IMPROVING FIBROSIS
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Pub. No.: WO/2018/054354 International Application No.: PCT/CN2017/102945
Publication Date: 29.03.2018 International Filing Date: 22.09.2017
IPC:
A61K 31/17 (2006.01) ,A61P 43/00 (2006.01) ,A61P 1/16 (2006.01) ,A61P 1/18 (2006.01) ,A61P 13/12 (2006.01) ,A61P 17/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
17
having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
18
for pancreatic disorders, e.g. pancreatic enzymes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
Applicants:
陈昆锋 CHEN, Kuen-Feng [CN/CN]; CN
萧崇玮 SHIAU, Chung-Wai [CN/CN]; CN
Inventors:
陈昆锋 CHEN, Kuen-Feng; CN
萧崇玮 SHIAU, Chung-Wai; CN
苏东弘 SU, Tung-Hung; CN
王诚一 WANG, Cheng-Yi; CN
Agent:
北京银龙知识产权代理有限公司 DRAGON INTELLECTUAL PROPERTY LAW FIRM; 中国北京市 海淀区西直门北大街32号院枫蓝国际中心2号楼10层 10F, Bldg. 2, Maples International Center No. 32 Xizhimen North Street, Haidian District Beijing 100082, CN
Priority Data:
62/398,27422.09.2016US
Title (EN) APPLICATION OF SRC HOMOLOGY REGION 2-CONTAINING PROTEIN TYROSINE PHOSPHATASE-1 AGONIST FOR IMPROVING FIBROSIS
(FR) APPLICATION D'UN AGONISTE DE PROTÉINE TYROSINE PHOSPHATASE 1 CONTENANT UNE RÉGION D'HOMOLOGIE SRC 2 POUR AMÉLIORER LA FIBROSE
(ZH) 含有SRC同源区2的蛋白酪氨酸磷酸酶-1激动剂用于改善纤维化的用途
Abstract:
(EN) Provided is an application of an SRC homology region 2-containing protein tyrosine phosphatase-1 agonist as represented by formula (I) in preparation of drugs for treating and reducing fibrosis. Preferably, the agonist is SC-43; the fibrosis is skin sclerosis or cardiac, pulmonary, hepatic, pancreatic, or renal fibrosis.
(FR) L'invention concerne une application d'un agoniste de protéine tyrosine phosphatase 1 contenant une région d'homologie SRC 2 représenté par la formule (I) dans la préparation de médicaments pour le traitement et la réduction de la fibrose. De préférence, l'agoniste est SC-43, la fibrose est une sclérose cutanée ou une fibrose cardiaque, pulmonaire, hépatique, pancréatique ou rénale.
(ZH) 提供一种含有SRC同源区2的蛋白酪氨酸磷酸酶-1激动剂式(I)在制备治疗、降低纤维化的药物中的用途,优选所述激动剂为SC-43,所述纤维化为皮肤硬化或心脏、肺、肝、胰或肾脏的纤维化。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)