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Pub. No.:    WO/2018/054241    International Application No.:    PCT/CN2017/101357
Publication Date: 29.03.2018 International Filing Date: 12.09.2017
C07K 16/40 (2006.01), C07K 16/00 (2006.01), C12N 15/13 (2006.01), C12N 15/00 (2006.01), A61K 39/395 (2006.01), A61K 39/00 (2006.01), A61P 3/06 (2006.01), A61P 3/00 (2006.01)
Applicants: WUXI BIOLOGICS (SHANGHAI) CO., LTD. [CN/CN]; 288 Fute Zhong Road Shanghai 200131 (CN)
Inventors: LIU, Jieying; (CN).
LI, Jing; (US)
Agent: JUN HE LAW OFFICES; 20/F China Resources Building 8 Jianguomenbei Avenue Beijing 100005 (CN)
Priority Data:
PCT/CN2016/099491 20.09.2016 CN
Abstract: front page image
(EN)Provided are monoclonal antibodies against Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9), which can block the binding of PCSK9 to LDL receptor, and therefore lower the level LDL-C. The antibodies of disclosure provide very potent agents for the treatment of multiple CVDs.
(FR)L'invention concerne des anticorps monoclonaux contre la proprotéine convertase subtilisine/kexine de type 9 (PCSK9) qui peuvent bloquer la liaison de la PCSK9 au récepteur des LDL et réduire ainsi le taux de cholestérol LDL. Les anticorps de l'invention fournissent des agents très puissants pour le traitement de diverses maladies cardiovasculaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)