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1. (WO2018053709) THE NOVEL MONOCLONAL ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1)

Pub. No.:    WO/2018/053709    International Application No.:    PCT/CN2016/099576
Publication Date: Fri Mar 30 01:59:59 CEST 2018 International Filing Date: Thu Sep 22 01:59:59 CEST 2016
IPC: C07K 16/28
C12N 15/13
C12N 15/63
C12N 5/10
C12N 5/20
A61K 39/395
A61P 35/00
Applicants: WUXI BIOLOGICS (SHANGHAI) CO., LTD.
Inventors: ZHENG, Yong
LI, Jing
GOLOLOBOV, Gennady
ZHANG, Xinhua
YANG, Baotian
TANG, Zhewei
LI, Dong
XU, Jianqing
WANG, Zhuozhi
Title: THE NOVEL MONOCLONAL ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1)
Abstract:
The present invention provides PD-1 monoclonal antibodies, particularly human monoclonal antibodies of PD-1, which specifically bind to PD-1 with high affinity and comprise a heavy chain and a light chain. The present invention further provides nucleic acid sequence encoding the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. Immunoconjugates, therapeutic compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating various cancers with anti-PD-1 antibodies.