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1. (WO2018053649) EPHA2 AND EPHA3-BINDING AGENTS AND USES THEREOF

Pub. No.:    WO/2018/053649    International Application No.:    PCT/CA2017/051128
Publication Date: Fri Mar 30 01:59:59 CEST 2018 International Filing Date: Tue Sep 26 01:59:59 CEST 2017
IPC: C07K 16/46
A61K 39/395
A61P 35/00
C07K 16/28
Applicants: MCMASTER UNIVERSITY
SIDHU, Sachdev
PAN, Guohua
ADAMS, Jarrett
MOFFAT, Jason
LONDON, Max Eliot
GORELIK, Maryna
Inventors: SIDHU, Sachdev
PAN, Guohua
ADAMS, Jarrett
MOFFAT, Jason
LONDON, Max Eliot
GORELIK, Maryna
VORA, Parvez
SINGH, Sheila
VENUGOPAL, Chitra
QAZI, Maleeha A.
Title: EPHA2 AND EPHA3-BINDING AGENTS AND USES THEREOF
Abstract:
Provided is an erythropoietin-producing hepatocellular carcinoma receptor (EphR)-binding agent comprising: a first binding agent which specifically binds a first EphR and a second binding agent which binds a second EphR, optionally EphA2 and EphA3. Also provided are uses of the EphR-binding agent for treating or preventing glioblastoma multiforme (GBM).