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1. (WO2018053529) METHOD OF TARGETING ONCOLYTIC VIRUSES TO TUMORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/053529 International Application No.: PCT/US2017/052313
Publication Date: 22.03.2018 International Filing Date: 19.09.2017
IPC:
A61K 35/28 (2006.01) ,A61K 39/39 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
Applicants: UNIVERSITY OF SOUTH FLORIDA[US/US]; 3802 Spectrum Blvd., Suite 100 Tampa, FL 33612-9220, US
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS[US/US]; 810 Vermont Avenue, N.W. Washington, DC 20420, US
Inventors: MOHAPATRA, Shyam, S.; US
MOHAPATRA, Subhra; US
Agent: LADWIG, Glenn, P.; US
EISENSCHENK, Frank, C.; US
LLOYD, Jeff; US
PACE, Doran, R.; US
LADWIG, Glenn, P.; US
Priority Data:
62/396,60419.09.2016US
Title (EN) METHOD OF TARGETING ONCOLYTIC VIRUSES TO TUMORS
(FR) PROCÉDÉ DE CIBLAGE DE VIRUS ONCOLYTIQUES AUX TUMEURS
Abstract:
(EN) The present invention pertains to a strategy of selectively targeting oncolytic virotherapy, using either naturally occurring or genetically modified viruses by packaging them in mesenchymal stem cells (MSCs). The present invention concerns MSCs, compositions comprising the MSCs, and methods of using the MSCs for treatment of cancer and for lysing or inducing apoptosis of cancer cells in vitro or in vivo.
(FR) La présente invention concerne une stratégie de ciblage sélectif de virothérapie oncolytique, utilisant soit des virus naturels soit des virus génétiquement modifiés par encapsulation de ceux-ci dans des cellules souches mésenchymateuses (MSC). La présente invention concerne des MSC, des compositions comprenant les MSC, et des procédés d'utilisation des MSC pour le traitement du cancer et pour la lyse ou induisant l'apoptose de cellules cancéreuses in vitro ou in vivo.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)