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1. (WO2018053506) CD80 AND CD86 BINDING PROTEIN COMPOSITIONS AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/053506    International Application No.:    PCT/US2017/052264
Publication Date: 22.03.2018 International Filing Date: 19.09.2017
IPC:
A61K 39/395 (2006.01), A61K 39/00 (2006.01), A61K 38/00 (2006.01), C07K 14/00 (2006.01)
Applicants: ONCOIMMUNE, INC. [US/US]; 12111 Parklawn Drive Suite 107 Rockville, MD 20852 (US).
CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER [US/US]; 111 Michigan Avenue, N.w. Washington, DC 20010 (US)
Inventors: LIU, Yang; (US).
DEVENPORT, Martin; (US).
ZHENG, Pan; (US).
WU, Wei; (US).
DU, Xuexiang; (US).
LIU, Mingyue; (US).
TANG, Fei; (US)
Agent: GALANT, Ron; (US).
WOOLLEY, Patrick, C.; (US)
Priority Data:
62/396,667 19.09.2016 US
Title (EN) CD80 AND CD86 BINDING PROTEIN COMPOSITIONS AND USES THEREOF
(FR) COMPOSITIONS DE PROTÉINE DE LIAISON À CD80 ET CD86 ET LEURS UTILISATIONS
Abstract: front page image
(EN)This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.
(FR)La présente invention concerne des compositions de protéine CTLA-4 et leur utilisation dans la réduction des événements indésirables auto-immuns associés à l'immunothérapie anticancéreuse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)