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1. (WO2018053432) IN VITRO PROPAGATION OF BABESIA MICROTI

Pub. No.:    WO/2018/053432    International Application No.:    PCT/US2017/052075
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Tue Sep 19 01:59:59 CEST 2017
IPC: A61K 39/018
C12N 1/10
C12N 1/00
Applicants: FULLER LABORATORIES
Inventors: FULLER, Lee
Title: IN VITRO PROPAGATION OF BABESIA MICROTI
Abstract:
A method for continuous in vitro propagation of Babesia microti and microti-like species is disclosed. The method comprises incubating B. microti in culture medium comprising host erythrocytes in the presence of a source of complement and a source of anti- B. microti IgM antibody. In one embodiment, the source of anti-B. microti IgM antibody is substantially free of IgG antibody. In one embodiment, the source of complement is a cell or cell line that secretes complement.