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1. (WO2018053432) IN VITRO PROPAGATION OF BABESIA MICROTI
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/053432    International Application No.:    PCT/US2017/052075
Publication Date: 22.03.2018 International Filing Date: 18.09.2017
IPC:
A61K 39/018 (2006.01), C12N 1/10 (2006.01), C12N 1/00 (2006.01)
Applicants: FULLER LABORATORIES [US/US]; 1312 E. Valencia Drive Fullerton, CA 92831 (US)
Inventors: FULLER, Lee; (US)
Agent: MALLON, Joseph, J.; (US)
Priority Data:
62/396,697 19.09.2016 US
62/506,429 15.05.2017 US
Title (EN) IN VITRO PROPAGATION OF BABESIA MICROTI
(FR) PROPAGATION IN VITRO DE BABESIA MICROTI
Abstract: front page image
(EN)A method for continuous in vitro propagation of Babesia microti and microti-like species is disclosed. The method comprises incubating B. microti in culture medium comprising host erythrocytes in the presence of a source of complement and a source of anti- B. microti IgM antibody. In one embodiment, the source of anti-B. microti IgM antibody is substantially free of IgG antibody. In one embodiment, the source of complement is a cell or cell line that secretes complement.
(FR)La présente invention concerne un procédé de propagation in vitro continue de Babesia microti et d’espèces de type microti. Le procédé comprend l’incubation de B. microti dans un milieu de culture comprenant des érythrocytes hôtes en présence d’une source de complément et d’une source d’anticorps IgM anti-B. microti. Dans un mode de réalisation, la source d’anticorps IgM anti-B. microti est sensiblement exempte d’anticorps IgG. Dans un mode de réalisation, la source de complément est une cellule ou une lignée cellulaire qui sécrète le complément.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)