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1. (WO2018053374) METHODS AND COMPOSITIONS FOR T-CELL EPITOPE SCREENING
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/053374 International Application No.: PCT/US2017/051938
Publication Date: 22.03.2018 International Filing Date: 16.09.2017
IPC:
G01N 33/53 (2006.01) ,C40B 30/06 (2006.01)
Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER[US/US]; Office of Technology Development 1275 York Avenue New York, NY 10065, US
Inventors: GEJMAN, Ron; US
SCHEINBERG, David, A.; US
Agent: GRIMES, Julia, Anne; US
YVON, Anne-marie, C.; US
Priority Data:
62/395,57716.09.2016US
Title (EN) METHODS AND COMPOSITIONS FOR T-CELL EPITOPE SCREENING
(FR) MÉTHODES ET COMPOSITIONS DE CRIBLAGE D'ÉPITOPES DE LYMPHOCYTES T
Abstract: front page image
(EN) The present invention provides new and improved methods for screening for and/or identifying T cell epitopes, as well as various assays and compositions (such as nucleic acid molecules, vectors, viruses, peptides, libraries, and cells), that are useful in carrying out such methods. Such methods and compositions can be used to predict and/or study the toxicity and off-target effects of T-cells, TCRs, or TCR-like molecules.
(FR) La présente invention concerne de nouvelles méthodes améliorées de criblage et/ou d'identification d'épitopes de lymphocytes T, ainsi que divers dosages et compositions (tels que des molécules d'acide nucléique, des vecteurs, des virus, des peptides, des bibliothèques et des cellules), qui sont utiles dans la mise en œuvre de telles méthodes. De telles méthodes et compositions peuvent être utilisées en vue de prédire et/ou d'étudier les effets de toxicité et hors cible de lymphocytes T, de TCR ou de molécules de type TCR.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)