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1. (WO2018053350) HIGH-EFFICIENCY TRANSFECTION OF BIOLOGICAL CELLS USING SONOPORATION

Pub. No.:    WO/2018/053350    International Application No.:    PCT/US2017/051909
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Sat Sep 16 01:59:59 CEST 2017
IPC: C12N 15/87
Applicants: LABCYTE INC.
Inventors: HARDEE, Jennifer M.
ELLSON, Richard N.
STEARNS, Richard G.
HADIMIOGLU, Babur
OLECHNO, Joseph D.
BLAUWKAMP, Marsha N.
Title: HIGH-EFFICIENCY TRANSFECTION OF BIOLOGICAL CELLS USING SONOPORATION
Abstract:
A method is provided for achieving transfection of host cells using sonoporation. An acoustic radiation generator is positioned in acoustic coupling relationship with respect to a reservoir containing host cells to be transfected, exogenous material to be incorporated into the host cells, and a cell-compatible fluid medium. The acoustic radiation generator is activated to generate acoustic radiation and direct the acoustic radiation into the reservoir in a manner effective to enable transfection of the host cells with the exogenous material.