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1. (WO2018053215) BETA-LACTAMASE INHIBITOR COMPOUNDS

Pub. No.:    WO/2018/053215    International Application No.:    PCT/US2017/051692
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Sat Sep 16 01:59:59 CEST 2017
IPC: C07D 471/08
C07D 211/78
A61K 31/439
A61P 31/04
Applicants: ENTASIS THERAPEUTICS LIMITED
Inventors: COMITA-PREVOIR, Janelle
DURAND-REVILLE, Thomas, Francois
GAUTHIER, Lise
O'DONNELL, John
ROMERO, Jan
TOMMASI, Ruben
VERHEIJEN, Jeroen, Cunera
WU, Frank
WU, Xiaoyun
ZHANG, Jing
BASARAB, Gregory, S.
MOSS, Bill
Title: BETA-LACTAMASE INHIBITOR COMPOUNDS
Abstract:
The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts are useful in combination with beta- lactam antibiotics, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of R1, R2, R3, R4, R5 and R6 are described herein.