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1. (WO2018053111) IN SITU GELLING COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF INFLAMMATION AND TISSUE DAMAGE

Pub. No.:    WO/2018/053111    International Application No.:    PCT/US2017/051538
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Fri Sep 15 01:59:59 CEST 2017
IPC: A61K 38/39
A61K 45/06
C07K 14/78
A61K 31/737
A61K 31/728
A61Q 11/00
Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION
GHANDAHARI, Hamidreza
OOTTAMASATHIEN, Siam
JESNEN, Mark Martin
CAPPELLO, Joseph
JIA, Wanjian
PRESTWICH, Glenn D.
Inventors: GHANDAHARI, Hamidreza
OOTTAMASATHIEN, Siam
JESNEN, Mark Martin
CAPPELLO, Joseph
JIA, Wanjian
PRESTWICH, Glenn D.
Title: IN SITU GELLING COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF INFLAMMATION AND TISSUE DAMAGE
Abstract:
Described herein are in situ gelling compositions. The compositions include an anti-inflammatory polysaccharide and a gelling polymer, wherein the composition is a liquid prior to administration to a subject but converts to a gel upon administration to the subject. The compositions described herein have numerous applications with respect to the local treatment (reduction or prevention) of inflammation and/or tissue damage.