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1. (WO2018053069) BLOCKADE OF ALPHAFETOPROTEIN (AFP) INTERACTIONS WITH BETA2-MICROGLOBULIN ASSOCIATED MOLECULES
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Pub. No.: WO/2018/053069 International Application No.: PCT/US2017/051462
Publication Date: 22.03.2018 International Filing Date: 14.09.2017
IPC:
A61K 39/395 (2006.01) ,A61K 38/38 (2006.01) ,A61P 37/06 (2006.01) ,C12P 21/02 (2006.01) ,C07K 14/47 (2006.01) ,C07K 14/76 (2006.01) ,C07K 14/765 (2006.01) ,C07K 14/74 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
38
Albumins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
76
Albumins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
76
Albumins
765
Serum albumin, e.g. HSA
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
74
Major histocompatibility complex (MHC)
Applicants:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street Boston, Massachusetts 02115, US
UNIVERSITY OF OSLO [NO/NO]; Inven2 AS P.O. Box 1061 Blindern N-0316 Oslo, NO
Inventors:
BLUMBERG, Richard, S.; US
PYZIK, Michal; US
GANDHI, Amit; US
SANDLIE, Inger; NO
SAND, Kine, Marita, Knudsen; NO
ANDERSEN, Jan, Terje; NO
Agent:
FITZGERALD, Mark, J.; US
RESNICK, David S.; US
EISENSTEIN, Ronald I.; US
BENN, Susanna C.; US
BRAICH, Ravinderjit S.; US
KARTTUNEN CONTARINO, Leena H.; US
CROSBY, David F.; US
HUFF, Shayne Y.; US
MILLS, Tari W.; US
PTASHKA, Teresa A.; US
SUMMERFORD, Candace M.; US
HSU WHITE, Jane; US
KLING, Nicole D.; US
TSE, Janet M.; US
Priority Data:
62/395,69616.09.2016US
Title (EN) BLOCKADE OF ALPHAFETOPROTEIN (AFP) INTERACTIONS WITH BETA2-MICROGLOBULIN ASSOCIATED MOLECULES
(FR) BLOCUS D'INTERACTIONS DE L'ALPHAFŒTOPROTÉINE (AFP) AVEC DES MOLÉCULES ASSOCIÉES À LA MICROGLOBULINE BÊTA2
Abstract:
(EN) Provided herein, in some aspects, are compositions and methods to inhibit AFP interactions with β2Μ and/or Class I-related molecule interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate AFP interactions with β2Μ and/or Class I-related molecule in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels is desired to increase immunosuppression or enhance organ regeneration.
(FR) Selon certains aspects, l'invention concerne des compositions et des méthodes permettant d'inhiber des interactions d'AFP avec la β2Μ et/ou des interactions avec une molécule de classe I dans des maladies ou des affections dans lesquelles des niveaux élevés d'AFP sont associés à une immunosuppression. L'invention concerne également, selon certains aspects, des compositions et des méthodes permettant de renforcer ou de potentialiser des interactions d'AFP avec la β2Μ et/ou une molécule de classe I dans des maladies ou des affections à niveaux d'AFP réduits ou dans des maladies ou des affections pour lesquelles une augmentation des niveaux d'AFP est souhaitée de façon à augmenter une immunosuppression ou à améliorer une régénération d'organe.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)