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1. (WO2018053053) PROXIMITY-DEPENDENT BIOTINYLATION AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/053053    International Application No.:    PCT/US2017/051428
Publication Date: 22.03.2018 International Filing Date: 13.09.2017
IPC:
A61K 48/00 (2006.01), C12N 9/22 (2006.01), C12N 15/63 (2006.01), C12N 15/79 (2006.01), G06F 19/16 (2011.01)
Applicants: THE BROAD INSTITUTE, INC. [US/US]; 415 Main Street Cambridge, MA 02142 (US).
CARR, Steven, A. [US/US]; (US).
WRIGHT, Jason [US/US]; (US).
MYERS, Sam [US/US]; (US)
Inventors: CARR, Steven, A.; (US).
WRIGHT, Jason; (US).
MYERS, Sam; (US)
Agent: NIX, Brent F.; (US)
Priority Data:
62/394,133 13.09.2016 US
Title (EN) PROXIMITY-DEPENDENT BIOTINYLATION AND USES THEREOF
(FR) BIOTINYLATION DÉPENDANT DU VOISINAGE ET SES UTILISATIONS
Abstract: front page image
(EN)The present invention provides fusion proteins, polynucleotides, kits, as well as TALE- or CRISPR-Cas based systems and methods. The present invention relies on proximity-dependent biotinylation, which allows site-directed protein or DNA purification and identification. The present invention provides tools for delineating the genetics of disease mechanism and for the identification of therapeutic targets and markers.
(FR)La présente invention concerne des protéines hybrides, des polynucléotides, des kits, ainsi que des systèmes et des procédés basés sur TALE- ou CRISPR-Cas. La présente invention repose sur une biotinylation dépendant du voisinage, qui permet la purification dirigée et l'identification de protéines ou d'ADN. La présente invention concerne des outils permettant de délimiter la génétique d'un mécanisme de maladie et d'identifier des cibles et des marqueurs thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)