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1. (WO2018053037) TARGETED ENHANCED DNA DEMETHYLATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/053037    International Application No.:    PCT/US2017/051411
Publication Date: 22.03.2018 International Filing Date: 13.09.2017
IPC:
A61K 38/00 (2006.01), A61K 38/46 (2006.01), C07K 14/315 (2006.01), C12N 5/00 (2006.01), C12N 9/22 (2006.01), C12N 15/09 (2006.01)
Applicants: THE JACKSON LABORATORY [US/US]; 600 Main Street Bar Harbor, ME 04609 (US)
Inventors: CHENG, Albert; (US).
TAGHBALOUT, Aziz; (US).
JILLETTE, Nathaniel; (US)
Agent: HETZER-EGGER, Claudia; (US).
; BAUER, John, A.; (US).
; AZRIN, Linda, B.; (US).
AMENDT, Kevin, C.; (US).
ADAMS, Lisa; (US)
Priority Data:
62/535,113 20.07.2017 US
62/485,210 13.04.2017 US
62/393,944 13.09.2016 US
Title (EN) TARGETED ENHANCED DNA DEMETHYLATION
(FR) DÉMÉTHYLATION D'ADN AMÉLIORÉE CIBLÉE
Abstract: front page image
(EN)Provided herein are, inter alia, compositions and methods for the delivery of enhanced demethylation activity to target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
(FR)La présente invention concerne, entre autres, des compositions et des méthodes pour la fourniture d'une activité de déméthylation accrue à des séquences d'ADN cibles dans une cellule de mammifère. Les compositions et les méthodes sont utiles pour la modulation de l'activité d'un gène ciblé, ou pour créer un réseau de régulation génique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)