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1. (WO2018052828) CHIMERIC ANTIGEN RECEPTORS COMPRISING BCMA-SPECIFIC FIBRONECTIN TYPE III DOMAINS AND USES THEREOF

Pub. No.:    WO/2018/052828    International Application No.:    PCT/US2017/050888
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Tue Sep 12 01:59:59 CEST 2017
IPC: A61K 39/00
C07K 16/28
Applicants: JANSSEN BIOTECH, INC.
Inventors: CHIN, Chen Ni
LEE, John
MCCABE, Timothy
MOONEY, Jill
NASO, Michael
STROHL, William
Title: CHIMERIC ANTIGEN RECEPTORS COMPRISING BCMA-SPECIFIC FIBRONECTIN TYPE III DOMAINS AND USES THEREOF
Abstract:
BCMA-specific fibronectin type III (FN3) domains, BCMA-targeting chimeric antigen receptors (CARs) comprising the FN3 domains, and engineered BCMA-targeting immune cells expressing the CARs are described. Also described are nucleic acids and expression vectors encoding the FN3 domains and the CARs, recombinant cells containing the vectors, and compositions comprising the engineered immune cells. Methods of making the FN3 domains, CARs, and engineered immune cells, and methods of using the engineered immune cells to treat diseases including cancer are also described.