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1. (WO2018052789) MONOCLONAL ANTIBODIES SPECIFIC TO THE PLEXIN-SEMAPHORIN-INTEGRIN (PSI) DOMAIN OF RON FOR DRUG DELIVERY AND ITS APPLICATION IN CANCER THERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/052789    International Application No.:    PCT/US2017/050448
Publication Date: 22.03.2018 International Filing Date: 07.09.2017
Chapter 2 Demand Filed:    16.03.2018    
IPC:
A61K 39/395 (2006.01), C07K 16/28 (2006.01), C07K 19/00 (2006.01), C12P 21/08 (2006.01)
Applicants: PCM TARGETECH, LLC [US/US]; 4805 Wesley Road, Suite 2C Amarillo, TX (US)
Inventors: WANG, Ming-Hai; (US).
YAO, Hang-Ping; (US)
Agent: FLORES, Edwin, S.; (US).
CLAUNCH, Chales; (US).
FLORES, Edwin, S.; (US).
CHALKER FLORES, LLP; Edwin S. Flores 14951 North Dallas Parkway, Suite 400 Dallas, TX 75254 (US)
Priority Data:
62/384,989 08.09.2016 US
Title (EN) MONOCLONAL ANTIBODIES SPECIFIC TO THE PLEXIN-SEMAPHORIN-INTEGRIN (PSI) DOMAIN OF RON FOR DRUG DELIVERY AND ITS APPLICATION IN CANCER THERAPY
(FR) ANTICORPS MONOCLONAUX SPÉCIFIQUES AU DOMAINE PSI (PLEXINE/SÉMAPHORINE/INTÉGRINE) DE RON POUR L'ADMINISTRATION DE MÉDICAMENT ET SON APPLICATION DANS UNE THÉRAPIE ANTICANCÉREUSE
Abstract: front page image
(EN)The present invention includes unique, isolated monoclonal antibodies that bind the PSI domain of human RON (RONPSI), and methods for making and using the same and novel combination therapies of anti-RONPSI antibodies, including humanized anti-RONPSI antibodies, nucleic acids that encode the heavy chain, the light chain, or both the light and heave chains of the antibody, host cells, expression vectors, and wherein the antibody or binding fragments thereof can be further conjugated with one or more cytotoxic or chemotherapeutic agents.
(FR)La présente invention comprend des anticorps monoclonaux isolés uniques qui se lient au domaine PSI du RON humain (RONPSI), et des procédés de fabrication et d'utilisation de ceux-ci et de nouvelles polythérapies d'anticorps anti-RONPSI, comprenant des anticorps anti-RONPSI humanisés, des acides nucléiques qui codent la chaîne lourde, la chaîne légère, ou les deux chaînes lourde et légères de l'anticorps, des cellules hôtes, des vecteurs d'expression, et l'anticorps ou leurs fragments de liaison pouvant être en outre conjugués avec un ou plusieurs agents cytotoxiques ou chimiothérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)