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1. (WO2018052142) GENETICALLY-MODIFIED CELLS AND METHOD FOR PRODUCING SAME
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Pub. No.: WO/2018/052142 International Application No.: PCT/JP2017/033582
Publication Date: 22.03.2018 International Filing Date: 15.09.2017
IPC:
C12N 15/09 (2006.01) ,A61K 31/7088 (2006.01) ,A61K 35/12 (2015.01) ,A61K 48/00 (2006.01) ,A61P 43/00 (2006.01) ,C07K 14/535 (2006.01) ,C07K 19/00 (2006.01) ,C12N 5/10 (2006.01) ,C12N 15/113 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
53
Colony-stimulating factor (CSF)
535
Granulocyte CSF; Granulocyte-macrophage CSF
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants:
キッセイ薬品工業株式会社 KISSEI PHARMACEUTICAL CO., LTD. [JP/JP]; 長野県松本市芳野19番48号 19-48, Yoshino, Matsumoto-shi, Nagano 3998710, JP
国立大学法人信州大学 SHINSHU UNIVERSITY [JP/JP]; 長野県松本市旭三丁目1番1号 1-1, Asahi 3-chome, Matsumoto-shi, Nagano 3908621, JP
Inventors:
中沢 洋三 NAKAZAWA Yozo; JP
松田 和之 MATSUDA Kazuyuki; JP
中野 茂 NAKANO Shigeru; JP
Agent:
特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES; 東京都港区愛宕二丁目5-1 愛宕グリーンヒルズMORIタワー32階 Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232, JP
Priority Data:
2016-18229316.09.2016JP
Title (EN) GENETICALLY-MODIFIED CELLS AND METHOD FOR PRODUCING SAME
(FR) CELLULES MODIFIÉES GÉNÉTIQUEMENT ET LEUR PROCÉDÉ DE PRODUCTION
(JA) 遺伝子改変細胞及びその作製方法
Abstract:
(EN) The purpose of the present invention is to produce chimeric antigen receptor (CAR)-expressing cells having superior target cell cytotoxicity. Provided are genetically-modified cells obtained by introducing polynucleotides that encode chimeric antigen receptor (CAR) proteins comprising a target binding domain that specifically binds to human granulocyte-macrophage colony-stimulating factor (GM-CSF), a transmembrane domain, and an intercellular signaling domain.
(FR) Le but de la présente invention est de produire des cellules exprimant un récepteur antigénique chimérique (CAR) possédant une une cytotoxicité de cellule cible supérieure. L'invention concerne des cellules génétiquement modifiées obtenues par introduction de polynucléotides qui codent pour des protéines de récepteur antigénique chimérique (CAR) comprenant un domaine de liaison cible qui se lie spécifiquement au facteur de stimulation de colonies de granulocytes-macrophages humains (GM-CSF), un domaine transmembranaire et un domaine de signalisation intercellulaire.
(JA) 優れた標的細胞傷害性を有するキメラ抗原受容体(CAR)発現細胞の作製。 ヒト顆粒球-マクロファージコロニー刺激因子(GM-CSF)受容体に特異的に結合する標的結合ドメインと、膜貫通ドメインと、細胞内シグナル伝達ドメインとを有するキメラ抗原受容体(CAR)タンパク質をコードするポリヌクレオチドが導入された遺伝子改変細胞を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)