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1. (WO2018052058) HETEROCYCLIC COMPOUND
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/052058 International Application No.: PCT/JP2017/033199
Publication Date: 22.03.2018 International Filing Date: 14.09.2017
IPC:
C07D 401/14 (2006.01) ,A61K 31/4439 (2006.01) ,A61P 29/00 (2006.01) ,A61P 37/06 (2006.01) ,A61P 43/00 (2006.01) ,C07D 413/14 (2006.01) ,C07D 487/10 (2006.01)
Applicants: TAKEDA PHARMACEUTICAL COMPANY LIMITED[JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP
Inventors: YOSHIDA, Masato; JP
TOMINARI, Yusuke; JP
SHIOKAWA, Zenyu; JP
SHIBUYA, Akito; JP
TAKAMI, Kazuaki; JP
GIBSON, Tony; US
SUZUKI, Shinkichi; JP
Agent: TAKASHIMA, Hajime; JP
KAMADA, Mitsunori; JP
Priority Data:
2016-18090315.09.2016JP
Title (EN) HETEROCYCLIC COMPOUND
(FR) COMPOSÉ HÉTÉROCYCLIQUE
(JA) 複素環化合物
Abstract: front page image
(EN) The present invention provides: a heterocyclic compound which has an IRAK-4-inhibiting activity and is expected to be useful for the prevention/treatment of inflammatory diseases, autoimmune diseases, osteoarticular degenerative diseases, neoplastic diseases and the like; and a medicine containing the heterocyclic compound. The present invention relates to a compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof.
(FR) La présente invention concerne : un composé hétérocyclique qui a une activité d'inhibition d'IRAK -4 et est supposé être utile pour la prévention/le traitement de maladies inflammatoires, des maladies auto-immunes, des maladies dégénératives ostéoarticulaires, des maladies néoplasiques et analogues ; et un médicament contenant le composé hétérocyclique. La présente invention concerne un composé représenté par la formule (I) [dans laquelle chaque symbole est tel que défini dans la description] ou un sel de celui-ci.
(JA) 本発明は、IRAK-4阻害作用を有し、炎症性疾患、自己免疫疾患、骨・関節変性疾患、腫瘍性疾患等の予防・治療に有用であると期待される複素環化合物およびそれを含有する医薬を提供する。 本発明は、式(I):[式中、各記号は明細書中で定義した通りである。] で表される化合物またはその塩に関する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)