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1. (WO2018051348) METHODS OF PURIFYING AND QUALIFYING ANTIBODIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/051348    International Application No.:    PCT/IL2017/051044
Publication Date: 22.03.2018 International Filing Date: 14.09.2017
IPC:
C07K 16/28 (2006.01), C07K 1/16 (2006.01), C07K 1/18 (2006.01), C07K 1/22 (2006.01), G01N 33/50 (2006.01), A61K 39/395 (2006.01)
Applicants: INSIGHT BIOPHARMACEUTICAL LTD. [IL/IL]; 12 HaMada Street 7670314 Rechovot (IL)
Inventors: MIRON, Daphna; (IL)
Agent: EHRLICH, Gal; (IL).
WATERMAN, Hadassa; (IL).
MELNICK, Geoffrey, L.; (IL)
Priority Data:
62/394,265 14.09.2016 US
Title (EN) METHODS OF PURIFYING AND QUALIFYING ANTIBODIES
(FR) PROCÉDÉS DE PURIFICATION ET DE QUALIFICATION D'ANTICORPS
Abstract: front page image
(EN)A method of purifying a recombinant antibody having the complementarity determining regions (CDRs) of denosumab, the method comprising subjecting a preparation comprising said antibody to a mixed mode chromatography on a Capto™ Adhere column in a pH range of 6.2-7.4, thereby purifying the antibody.
(FR)L'invention concerne un procédé de purification d'un anticorps de recombinaison ayant les régions de détermination de complémentarité (CDR) de dénosumab, le procédé comprenant l'étape consistant à soumettre une préparation comprenant ledit anticorps à une chromatographie en mode mixte sur une colonne d'adhérence Capto™ dans une plage de pH de 6,2 à 7,4, ce qui permet de purifier l'anticorps.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)