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1. (WO2018051255) CYCLIC SUBSTITUTED-1,3,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/051255    International Application No.:    PCT/IB2017/055547
Publication Date: 22.03.2018 International Filing Date: 14.09.2017
IPC:
C07D 291/00 (2006.01), C07D 285/08 (2006.01), A61K 31/4245 (2006.01), A61K 31/433 (2006.01), A61P 31/00 (2006.01), A61P 35/00 (2006.01)
Applicants: AURIGENE DISCOVERY TECHNOLOGIES LIMITED [IN/IN]; 39-40, KIADB Industrial Area, Electronic City Phase II, Hosur Road, Karnataka Bangalore 560100 (IN)
Inventors: SASIKUMAR, Pottayil Govindan Nair; (IN).
PRASAD, Appukkuttan; (IN).
NAREMADDEPALLI, Seetharamaiah Setty Sudarshan; (IN).
RAMACHANDRA, Muralidhara; (IN)
Priority Data:
201641031319 14.09.2016 IN
Title (EN) CYCLIC SUBSTITUTED-1,3,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS
(FR) COMPOSÉS CYCLIQUES SUBSTITUÉS DE 1,3,4-OXADIAZOLE ET THIADIAZOLE UTILISÉS EN TANT QU'IMMUNOMODULATEURS
Abstract: front page image
(EN)The present invention relates to cyclic substituted 1,3,4-oxadiazole and thiadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
(FR)La présente invention concerne des composés cycliques substitués de 1,3,4-oxadiazole et thiadiazole de formule (I) et leur utilisation dans l'inhibition de la voie de signalisation de la mort cellulaire programmée 1 (PD-1) et/ou pour le traitement de troubles par l'inhibition d'un signal immunosuppresseur induit par PD-1, PD-L1 ou PD-L2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)