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1. (WO2018051197) CHIRAL CYCLEN COMPOUNDS AND THEIR USES

Pub. No.:    WO/2018/051197    International Application No.:    PCT/IB2017/053771
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Sat Jun 24 01:59:59 CEST 2017
IPC: C07D 257/02
A61K 31/395
A61K 49/22
Applicants: THE HONG KONG POLYTECHNIC UNIVERSITY
Inventors: LAW, Ga-Lai
DAI, Lixiong
Title: CHIRAL CYCLEN COMPOUNDS AND THEIR USES
Abstract:
The present invention relates to the preparation of a series of chiral DOTA, D03A, D02A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA- based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.