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Pub. No.:    WO/2018/051175    International Application No.:    PCT/IB2017/000751
Publication Date: 22.03.2018 International Filing Date: 24.05.2017
C07K 14/00 (2006.01), C07K 7/08 (2006.01), C12N 15/113 (2010.01), A61K 38/00 (2006.01)
Applicants: OLIPASS CORPORATION [KR/KR]; 20th Floor, Ace Dongbaek Tower 16 Beon-gil, 16-4 Dongbaek Jungang-ro Giheung-gu, Yongin-si, Gyeonggi-do 17015 (KR)
Inventors: CHUNG, Shin; (KR).
JUNG, Daram; (KR).
CHO, Bongjun; (KR).
JANG, Kangwon; (KR).
YOON, Heungsik; (KR)
Priority Data:
62/395,814 16.09.2016 US
Abstract: front page image
(EN)The current invention provides peptide nucleic acid derivatives targeting a part of the human SCN9A pre-mRNA. The peptide nucleic acid derivatives potently induce splice variants of the SCN9A mRNA in cells, and are useful to safely treat pains or conditions involving Nav1.7 activity.
(FR)La présente invention concerne des dérivés d'acide nucléique peptidique ciblant une partie du pré-ARNm de SCN9A humain. Les dérivés d'acide nucléique peptidique induisent puissamment des variants d'épissage de l'ARNm de SCN9A dans les cellules, et sont utiles pour traiter en toute sécurité des douleurs ou des états impliquant une activité de Nav1.7.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)