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1. (WO2018050818) GENERATION OF HPV-SPECIFIC T-CELLS

Pub. No.:    WO/2018/050818    International Application No.:    PCT/EP2017/073274
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Sat Sep 16 01:59:59 CEST 2017
IPC: C12N 5/0783
Applicants: BAYLOR COLLEGE OF MEDICINE
CLEGG, Richard Ian
Inventors: RAMOS, Carlos A.
ROONEY, Cliona M.
NARALA, Neeharika
Title: GENERATION OF HPV-SPECIFIC T-CELLS
Abstract:
Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of HPV16 and/or HPV18, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-6 and/or IL-12. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells.