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1. (WO2018050818) GENERATION OF HPV-SPECIFIC T-CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/050818    International Application No.:    PCT/EP2017/073274
Publication Date: 22.03.2018 International Filing Date: 15.09.2017
IPC:
C12N 5/0783 (2010.01)
Applicants: BAYLOR COLLEGE OF MEDICINE [US/US]; One Baylor Plaza Houston, Texas 77030 (US).
CLEGG, Richard Ian [GB/GB]; (GB) (LS only)
Inventors: RAMOS, Carlos A.; (US).
ROONEY, Cliona M.; (US).
NARALA, Neeharika; (US)
Agent: CLEGG, Richard; (GB).
ADDISS, John; (GB).
ANDREWS, Robert; (GB).
BAILEY, Sam; (GB).
BRASNETT, Adrian; (GB).
BREARLEY, Sarah; (GB).
BURNS, Alex; (GB).
CARLISLE, Julie; (GB).
CARTER, Stephen; (GB).
CASLEY, Christopher; (GB).
CRIPPS, Joanna; (GB).
DALE, Elizabeth; (GB).
DENISON, Christopher; (GB).
DUNNE, Paul; (GB).
FORREST, Graham; (GB).
FURNIVAL, Tom; (GB).
GILL, Stephen; (GB).
GRAHAM, Emma; (GB).
GREEN, Katherine; (GB).
GREGORY, Adam; (GB).
HARRISON, Susan; (GB).
HAYES, Emily; (GB).
HODSDON, Stephen; (GB).
JOHNSON, Richard; (GB).
JONES, Rachel; (GB).
KEIRSTEAD, Tanis; (GB).
KIDDLE, Simon; (GB).
KREMER, Simon; (GB).
LEACH, James; (GB).
LENTHALL, Joseph; (GB).
LYONS, June; (GB).
MACIVER, Eleanor; (GB).
MCGUINN, Callum; (GB).
MOELLER, Christoph; (GB).
MOORE, Graeme; (GB).
NAYLOR, Matthew; (GB).
OXLEY, Rachel; (GB).
PARRY, Simon; (GB).
SALISBURY, Frances; (GB).
SMITH, Matthew; (GB).
STONER, Patrick; (GB).
SUTCLIFFE, Nicholas; (GB).
THORNTON, Dan; (GB).
TOLLERVEY, Rebecca; (GB).
WALTON, Seán; (GB).
WARD, Eliot; (GB).
WATSON, Robert; (GB).
WEBSTER, Jeremy; (GB).
WESCOTT, Rhiannon; (GB).
WILLS, Jonathan; (GB).
WYTENBURG, Wilhelmus; (GB)
Priority Data:
62/395,440 16.09.2016 US
15/331,659 21.10.2016 US
Title (EN) GENERATION OF HPV-SPECIFIC T-CELLS
(FR) GÉNÉRATION DE CELLULES T SPÉCIFIQUES DU HPV
Abstract: front page image
(EN)Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of HPV16 and/or HPV18, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-6 and/or IL-12. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells.
(FR)Des modes de réalisation de l'invention concernent des méthodes et des compositions destinées à l'immunothérapie contre les infections à papillomavirus humain et maladies associées à ces dernières. Dans des modes de réalisation spécifiques, les méthodes concernent la production de cellules immunitaires ciblant un ou plusieurs antigènes du HPV16 et/ou du HPV18, y compris des méthodes comprenant des étapes de stimulation qui utilisent l'IL-7 et l'IL-15, mais pas l'IL-6 et/ou l'IL-12. D'autres modes de réalisation spécifiques utilisent des stimulations en présence de certaines cellules, telles que des cellules co-stimulatrices et certaines cellules présentatrices d'antigène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)