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1. (WO2018050815) AMIDE DERIVATIVES OF SQUALAMINE FOR THE TREATMENT OF INFECTIONS

Pub. No.:    WO/2018/050815    International Application No.:    PCT/EP2017/073267
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Sat Sep 16 01:59:59 CEST 2017
IPC: C07J 41/00
C07J 9/00
A61K 31/575
A61P 31/04
A61P 31/10
A61P 31/12
A61P 33/00
Applicants: VIRBAC
Inventors: BRUNEL, Jean-Michel
BLANCHET, Marine
MARC, Jean-Pascal
Title: AMIDE DERIVATIVES OF SQUALAMINE FOR THE TREATMENT OF INFECTIONS
Abstract:
The present invention relates to a compound of formula (I), in which R’ represents a -(CRaRb)n-X-(CRcRd)m-[Y-(CReRf)o]t-NR9R10 group, and X and Y independently represent a -NR11- group, an –O- group or a divalent heterocyclic group comprising at least one nitrogen atom, with 5 or 6 members; as well as the stereoisomers, stereoisomer mixtures, and/or pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical or veterinary compositions containing same, and to the use of said compositions as a drug, more particularly in the treatment of bacterial, fungal, viral or parasitic infections. The invention further relates to the pharmaceutical or veterinary compositions comprising such a compound of formula (I) in combination with an antibiotic different from such a compound of formula (I).