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1. (WO2018050733) ANTI-C-MET ANTIBODIES AND ANTIBODY DRUG CONJUGATES THEREOF FOR EFFICIENT TUMOR INHIBITION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/050733    International Application No.:    PCT/EP2017/073106
Publication Date: 22.03.2018 International Filing Date: 14.09.2017
IPC:
C07K 16/28 (2006.01), A61K 47/68 (2017.01)
Applicants: MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt (DE)
Inventors: DOERNER, Achim; (DE).
TOLEIKIS, Lars; (DE).
PIATER, Birgit; (DE).
RHIEL, Laura; (DE).
KNUEHL, Christine; (DE).
SELLMANN, Carolin; (DE).
KRAH, Simon; (DE)
Priority Data:
16188857.3 14.09.2016 EP
Title (EN) ANTI-C-MET ANTIBODIES AND ANTIBODY DRUG CONJUGATES THEREOF FOR EFFICIENT TUMOR INHIBITION
(FR) ANTICORPS ANTI-C-MET ET CONJUGUÉS MÉDICAMENT-ANTICORPS DE CEUX-CI POUR UNE INHIBITION EFFICACE DES TUMEURS
Abstract: front page image
(EN)The present invention provides antibodies and heterodimeric immunoglobulin molecules, which bind cMET with high affinity and can be used to target cMET expressing tumor cells. The present invention also discloses methods of generating anti-cMET antibody drug conjugates using the inventive antibodies or heterodimeric immunoglobulin molecules as disclosed herein.
(FR)La présente invention concerne des anticorps et des molécules d'immunoglobulines hétérodimères, qui se lient à cMET avec une affinité élevée et peuvent être utilisés pour cibler des cellules tumorales exprimant cMET. La présente invention concerne également des procédés de génération de conjugués médicament-anticorps anti-cMET à l'aide des anticorps de l'invention ou des molécules d'immunoglobulines hétérodimères selon l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)