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1. (WO2018050733) ANTI-C-MET ANTIBODIES AND ANTIBODY DRUG CONJUGATES THEREOF FOR EFFICIENT TUMOR INHIBITION

Pub. No.:    WO/2018/050733    International Application No.:    PCT/EP2017/073106
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Fri Sep 15 01:59:59 CEST 2017
IPC: C07K 16/28
A61K 47/68
Applicants: MERCK PATENT GMBH
Inventors: DOERNER, Achim
TOLEIKIS, Lars
PIATER, Birgit
RHIEL, Laura
KNUEHL, Christine
SELLMANN, Carolin
KRAH, Simon
Title: ANTI-C-MET ANTIBODIES AND ANTIBODY DRUG CONJUGATES THEREOF FOR EFFICIENT TUMOR INHIBITION
Abstract:
The present invention provides antibodies and heterodimeric immunoglobulin molecules, which bind cMET with high affinity and can be used to target cMET expressing tumor cells. The present invention also discloses methods of generating anti-cMET antibody drug conjugates using the inventive antibodies or heterodimeric immunoglobulin molecules as disclosed herein.