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1. (WO2018050684) FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/050684 International Application No.: PCT/EP2017/073001
Publication Date: 22.03.2018 International Filing Date: 13.09.2017
IPC:
C07D 519/04 (2006.01) ,A61P 35/00 (2006.01) ,A61P 3/10 (2006.01)
Applicants: JANSSEN PHARMACEUTICA NV[BE/BE]; Turnhoutseweg 30 2340 Beerse, BE
Inventors: ANGIBAUD, Patrick, René; FR
PANDE, Vineet; BE
HERKERT, Barbara; BE
KROSKY, Daniel, Jason; US
QUEROLLE, Olivier, Alexis, Georges; FR
PATRICK, Aaron Nathaniel; US
Agent: LENAERTS, Philip; BE
Priority Data:
16192424.605.10.2016EP
17180228.307.07.2017EP
62/394,29114.09.2016US
Title (EN) FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION
(FR) INHIBITEURS BICYCLIQUES FUSIONNÉS DE L'INTERACTION MÉNINE-MLL
Abstract:
(EN) The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to fused bicyclic compounds, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes.
(FR) La présente invention concerne des agents pharmaceutiques utiles pour la thérapie et/ou la prophylaxie chez un mammifère, et en particulier des composés bicycliques fusionnés, une composition pharmaceutique comprenant de tels composés, et leur utilisation en tant qu'inhibiteurs d'interactions ménine/protéine MLL/protéine, utiles pour le traitement de maladies telles que le cancer, le syndrome myélodysplasique (MDS) et le diabète.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)