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1. (WO2018050671) NIDOGEN-1 FRAGMENTS ASSAY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/050671    International Application No.:    PCT/EP2017/072973
Publication Date: 22.03.2018 International Filing Date: 13.09.2017
IPC:
C07K 14/78 (2006.01), C12Q 1/37 (2006.01), G01N 33/574 (2006.01)
Applicants: NORDIC BIOSCIENCE A/S [DK/DK]; Herlev Hovedgade 207 2730 Herlev (DK)
Inventors: WILLUMSEN, Nicholas; (DK).
BAGER, Cecilie, Liv; (DK).
BAY JENSEN, Anne-Cecilie; (DK).
QUILEZ-ALVAREZ, Antonio; (ES).
KARSDAL, Morten; (DK).
ORSNES-LEEMING, Diana; (DK).
MANON-JENSEN, Tina; (DK)
Agent: BECK GREENER; 12 Fulwood Place London WC1V 6HR (GB)
Priority Data:
1615746.3 15.09.2016 GB
Title (EN) NIDOGEN-1 FRAGMENTS ASSAY
(FR) DOSAGE DE FRAGMENTS DE NIDOGÈNE -1
Abstract: front page image
(EN)A method of diagnosis or of quantitation of cancer comprising obtaining a patient biofluid sample, conducting an immunoassay to measure fragments of Nidogen-1 having an N- or C-terminal neo-epitope formed by cleavage of Nidogen-1 by Cathepsin-S, said fragments being naturally present in said sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of cancer.
(FR)L'invention concerne un procédé de diagnostic ou de quantification du cancer comprenant l'obtention d'un échantillon biofluide de patient, la réalisation d'un dosage immunologique pour mesurer des fragments de Nidogène -1 ayant un néo-épitope N-ou C-terminal formé par clivage de Nidogène -1 par la Cathepsine-S, lesdits fragments étant naturellement présents dans ledit échantillon, et l'association d'une élévation de ladite mesure dans ledit patient au-dessus d'un niveau normal avec la présence ou l'étendue du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)