Search International and National Patent Collections

1. (WO2018049925) METHOD FOR SCREENING ANTI-BREAST CANCER METASTASIS COMPOUND AND APPLICATION OF RELATED COMPOUND

Pub. No.:    WO/2018/049925    International Application No.:    PCT/CN2017/094478
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Thu Jul 27 01:59:59 CEST 2017
IPC: C12Q 1/68
C12N 15/11
A61K 38/12
A61K 31/23
A61K 31/4409
A61K 31/365
A61K 31/353
A61K 31/437
A61K 31/166
A61K 31/192
A61K 31/12
Applicants: TSINGHUA UNIVERSITY
清华大学
Inventors: SHAO, Wei
邵伟
LI, Shasha
李莎莎
WANG, Dong
王栋
Title: METHOD FOR SCREENING ANTI-BREAST CANCER METASTASIS COMPOUND AND APPLICATION OF RELATED COMPOUND
Abstract:
A method for screening an anti-breast cancer metastasis compound by using a tumor metastasis gene profile comprises randomly selecting at least one gene from the following 18 genes: MMP1, FSCN1, PTGS2, EREG, ANGPTL4, VCAM1, CXCR4, CXCL1, RARRES3, ID1, TNC, LY6E, LTBP1, C10orf116, KRTHB1, KYNU, MAN1A1, and NEDD9; and then designing a probe to select a compound that causes the expression levels of these metastasis genes in metastasized breast cancer cells to transition to those in cancer cells in situ or normal cells. Twenty compounds were selected using the method, and cytotoxicity and animal-level experiments demonstrated that these compounds or combinations thereof all exhibited activity against breast cancer metastasis at different degrees.