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|1. (WO2018049535) NUCLEOSIDE ANALOGUES AND METHODS OF USE THEREOF|
|Applicants:||LCB PHARMA INC.
|Title:||NUCLEOSIDE ANALOGUES AND METHODS OF USE THEREOF|
Nucleoside analogues that can be used as anticancer or antiviral agents are presented. These compounds are nucleoside and/or nucleotide prodrugs. In particular, the subject matter relates to nucleoside analogues comprising a tetrahydrofuranyl, or tetrahydrothienyl moiety which: have a quaternary stereogenic all-carbon center at the 3' position and bear a phosphoryl group at either one of, or both of positions C5' and/or C3'; have a quaternary stereogenic all-carbon center at one of the 3' position, 2' position, or no quaternary stereogenic center at all, and bear a β-blocked lipoate derivative attached through an amide bond to the primary amine of the nucleobase; or have a quaternary stereogenic all-carbon center at the 2' position and bear a phosphorylated prodrug at the C5'-position and a β-blocked lipoate derivative attached through an amide bond to the primary amine of the nucleobase.