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1. (WO2018049471) REAGENTS FOR PRODUCING T-CELLS WITH NON-FUNCTIONAL T-CELL RECEPTORS (TCRs) COMPOSITIONS COMPRISING SAME AND USE THEREOF

Pub. No.:    WO/2018/049471    International Application No.:    PCT/AU2017/050995
Publication Date: Fri Mar 23 00:59:59 CET 2018 International Filing Date: Fri Sep 15 01:59:59 CEST 2017
IPC: C12N 15/113
A61K 31/713
Applicants: BENITEC BIOPHARMA LIMITED
Inventors: GARCIA, Patty Bertha
STRINGS-UFOMBAH, Vanessa
ROELVINK, Peter
GRAHAM, Michael
SUHY, David
Title: REAGENTS FOR PRODUCING T-CELLS WITH NON-FUNCTIONAL T-CELL RECEPTORS (TCRs) COMPOSITIONS COMPRISING SAME AND USE THEREOF
Abstract:
The present disclosure relates to reagents for producing T-cells comprising non- functional T-cell receptors (TCR), including T-cells which also express chimeric antigen receptors (CAR), i.e., CAR-T cells, compositions comprising said reagents and T-cells, and uses of said CAR-T cells in therapy e.g., adoptive therapy.