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1. (WO2018049284) DELIVERY OF NUCLEIC ACIDS, PROTEINS AND SMALL MOLECULES IN VITREOUS VESICULAR BODIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/049284    International Application No.:    PCT/US2017/050854
Publication Date: 15.03.2018 International Filing Date: 09.09.2017
IPC:
C12N 15/11 (2006.01), A61K 48/00 (2006.01), A61K 38/00, C12N 15/00 (2006.01), C07H 21/04 (2006.01)
Applicants: CORNELL UNIVERSITY [US/US]; Center for Technology Licensing at Cornell University (CTL) 395 Pine Tree Road, Suite 310 Ithaca, NY 14850 (US)
Inventors: PENA, John, TG; (US).
GUPTA, Mrinali, Patel; (US).
D'AMICO, Donald, J.; (US)
Agent: CHILDS, Carissa, R.; (US).
GOLDMAN, Michael, L.; (US).
MERKEL, Edwin, V.; (US).
TISCHNER, Tate, L.; (US).
O'GARA, Megan, T.; (US)
Priority Data:
62/385,711 09.09.2016 US
Title (EN) DELIVERY OF NUCLEIC ACIDS, PROTEINS AND SMALL MOLECULES IN VITREOUS VESICULAR BODIES
(FR) ADMINISTRATION D'ACIDES NUCLÉIQUES, DE PROTÉINES ET DE PETITES MOLÉCULES DANS DES CORPS VÉSICULAIRES VITREUX
Abstract: front page image
(EN)The present invention relates to compositions of aqueous humor and/or vitreous humor derived extracellular vesicles and their use for the delivery of therapeutic agents to ocular tissues for the treatment of ophthalmic diseases. Further disclosed are methods of making the compositions. Methods of treating and diagnosing an ocular condition are also disclosed.
(FR)La présente invention concerne des compositions de vésicules extracellulaires issues de l'humeur aqueuse et/ou de l'humeur vitrée et leur utilisation pour l'administration d'agents thérapeutiques à des tissus oculaires en vue du traitement de maladies ophtalmiques. L'invention concerne également des procédés de production des compositions. L'invention concerne en outre des procédés de traitement et de diagnostic d'une affection oculaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)