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1. (WO2018049268) BIOMARKERS FOR THE DIAGNOSIS AND CHARACTERIZATION OF ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/049268 International Application No.: PCT/US2017/050831
Publication Date: 15.03.2018 International Filing Date: 08.09.2017
IPC:
G01N 33/50 (2006.01) ,A61K 31/661 (2006.01) ,G01N 33/92 (2006.01)
Applicants: TOLEDO, Jon, B.[US/US]; US
ARNOLD, Matthias[DE/DE]; DE
KASTEMULLER, Gabi[DE/DE]; DE
BAILLIE, Rebecca, A.[US/US]; US
HAN, Xianlin[US/US]; US
THOMPSON, Will[US/US]; US
ST. JOHN-WILLIAMS, Lisa[US/US]; US
KOAL, Therese[AT/AT]; AT
MOSELEY, M., Arthur[US/US]; US
SAYKIN, Andrew, J.[US/US]; US
DORAISWAMY, Pudugramam, Murali[IN/US]; US
DUKE UNIVERSITY[US/US]; 2812 Erwin Road Suite 306 Durham, NC 27705, US
UNIVERSITY OF PENNSYLVANIA[US/US]; Philadelphia, PA, US
HOUSTON METHODIST HOSPITAL[US/US]; Houston, TX, US
HELMHOLTZ ZENTRUM MUNCHEN[DE/DE]; Neuherberg, DE
GERMAN CENTER FOR DIABETES RESEARCH (DZD)[DE/DE]; Neuherberg, DE
ROSA & CO LLC[US/US]; San Carlos, CA, US
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE[US/US]; Orlando, FL, US
INDIANA UNIVERSITY SCHOOL OF MEDICINE; Indianapolis, IN, US
BIOCRATES LIFE SCIENCES AG[AT/AT]; Innsbruck, AT
NHO, Kwangsik[US/US]; US
Inventors: TOLEDO, Jon, B.; US
ARNOLD, Matthias; DE
KASTEMULLER, Gabi; DE
BAILLIE, Rebecca, A.; US
HAN, Xianlin; US
THOMPSON, Will; US
ST. JOHN-WILLIAMS, Lisa; US
KOAL, Therese; AT
MOSELEY, M., Arthur; US
SAYKIN, Andrew, J.; US
DORAISWAMY, Pudugramam, Murali; US
Agent: SCHLUETER, Peter, J.; US
Priority Data:
62/384,85408.09.2016US
Title (EN) BIOMARKERS FOR THE DIAGNOSIS AND CHARACTERIZATION OF ALZHEIMER'S DISEASE
(FR) BIOMARQUEURS POUR LE DIAGNOSTIC ET LA CARACTÉRISATION DE LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN) Embodiments of the present disclosure relate generally to the analysis and identification of global metabolic changes in Alzheimer's disease (AD). More particularly, the present disclosure provides materials and methods relating to the use of metabolornics as a biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance. Defining metabolic changes during AD disease trajectory and their relationship to clinical phenotypes provides a powerful roadmap for drug and biomarker discovery.
(FR) Des modes de réalisation de la présente invention concernent de manière générale l'analyse et l'identification de changements métaboliques d'ensemble dans la maladie d'Alzheimer. Plus particulièrement, la présente invention concerne des substances et des procédés se rapportant à l'utilisation de la métabolonique en tant que démarche biochimique d'identification de changements métaboliques périphériques chez les patients atteints de la maladie d'Alzheimer et de mise en corrélation de ceux-ci avec des marqueurs pathologiques du liquide céphalorachidien, des caractéristiques d'imagerie et les performances cognitives. La définition des changements métaboliques au cours de la maladie d'Alzheimer et de leur relation avec des phénotypes cliniques fournit une feuille de route efficace pour la découverte de médicaments et de biomarqueurs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)