WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018049248) ONCOLYTIC VIRUS EQUIPPED WITH BISPECIFIC ENGAGER MOLECULES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/049248    International Application No.:    PCT/US2017/050803
Publication Date: 15.03.2018 International Filing Date: 08.09.2017
IPC:
A61K 35/768 (2015.01), C07K 16/28 (2006.01), C07K 16/30 (2006.01), C07K 16/40 (2006.01), C12N 7/00 (2006.01)
Applicants: ICELLHEALTH CONSULTING LLC [US/US]; 3012 Rocky Point Dr. Pearland, TX 77584 (US)
Inventors: SONG, Xiaotong; (US)
Agent: XIAO, Jian; (US).
AHN, Sejin; (US).
ARJOMAND, Mehran; (US).
BANKO, Max; (US).
AIKEN, Chrity; (US)
Priority Data:
62/385,930 09.09.2016 US
62/385,933 09.09.2016 US
Title (EN) ONCOLYTIC VIRUS EQUIPPED WITH BISPECIFIC ENGAGER MOLECULES
(FR) VIRUS ONCOLYTIQUE ÉQUIPÉ DE MOLÉCULES D'ENGAGEMENT BISPÉCIFIQUES
Abstract: front page image
(EN)The present invention provides an oncolytic virus encoding a bispecific molecule specifically recognizing (i) a tumor antigen (such as EphCAM) and (ii) a cell surface molecule on an effector cell, such as CD3 on T lymphocytes. The the bispecific molecule has low-binding affinity for both tumor antigen and cell surface molecule. Pharmaceutical compositions for cancer treatment, and the corresponding medical uses, of the oncolytic virus described herein are also provided. Novel anti-EpCAM antibodies, and nucleic acids encoding them, are also provided.
(FR)La présente invention concerne un virus oncolytique codant pour une molécule bispécifique reconnaissant spécifiquement (i) un antigène tumoral (tel que EphCAM) et (ii) une molécule de surface cellulaire d'une cellule effectrice, telle que le CD3 des cellules T. La molécule bispécifique présente une faible affinité de liaison à la fois pour l'antigène tumoral et pour la molécule de surface cellulaire. L'invention concerne également des compositions pharmaceutiques du virus oncolytique de l'invention destinées au traitement du cancer, et les utilisations médicales correspondantes. L'invention concerne également de nouveaux anticorps anti-EpCAM, et les acides nucléiques codant pour ces derniers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)