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1. (WO2018049042) METHODS AND COMPOSITIONS FOR TREATING CANCERS BY INHIBITING ESTROGEN SIGNALING IN MYELOID-DERIVED SUPPRESSOR CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/049042 International Application No.: PCT/US2017/050500
Publication Date: 15.03.2018 International Filing Date: 07.09.2017
IPC:
A61P 35/04 (2006.01) ,G01N 33/50 (2006.01) ,G01N 33/74 (2006.01) ,A61K 31/415 (2006.01) ,A61K 39/395 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/30 (2006.01)
Applicants: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY[US/US]; 3601 Spruce Street Philadelphia, PA 19104, US
Inventors: CONEJO-GARCIA, Jose, R.; US
SVORONOS, Nikolaos, A.; US
Agent: WALLS, Thomas, H.; US
BEARDELL, Louis, W.; US
CHAI, Deping; US
DAVIS, Kenneth, J.; US
GRIFFIN, Gail, H.; US
Priority Data:
62/384,56307.09.2016US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING CANCERS BY INHIBITING ESTROGEN SIGNALING IN MYELOID-DERIVED SUPPRESSOR CELLS
(FR) MÉTHODES ET COMPOSITIONS PERMETTANT DE TRAITER DES CANCERS PAR L'INHIBITION DE LA SIGNALISATION DES ŒSTROGÈNES DANS DES CELLULES SUPPRESSIVES DÉRIVÉES DE CELLULES MYÉLOÏDES
Abstract: front page image
(EN) Compositions and methods are provided for treating an estrogen receptor negative cancer in a subject with an elevated population of estrogen receptor positive myeloid-derived suppressor cells (MDSCs), including administering a therapeutically effective amount of an estrogen receptor antagonist to the subject in need thereof.
(FR) La présente invention concerne des compositions et des méthodes permettant de traiter un cancer négatif au récepteur des œstrogènes chez un sujet présentant une population élevée de cellules suppressives dérivées de cellules myéloïdes positives au récepteur des œstrogènes (MDSC)), comprenant l'administration d'une quantité thérapeutiquement efficace d'un antagoniste du récepteur des œstrogènes au sujet qui en a besoin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)