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1. (WO2018048977) DEUTERIUM-SUBSTITUTED OXAZEPIN COMPOUNDS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/048977    International Application No.:    PCT/US2017/050395
Publication Date: 15.03.2018 International Filing Date: 07.09.2017
IPC:
C07D 413/06 (2006.01), A61K 31/506 (2006.01), A61P 9/00 (2006.01)
Applicants: AUSPEX PHARMACEUTICALS, INC. [US/US]; 41 Moores Road Frazer, PA 19355 (US)
Inventors: FISHER, Richard; (IL).
ZHANG, Chengzhi; (US)
Agent: VALLA, S., Maurice; (US).
PALOVICH, Tracy, U.; (US).
LODISE, Stephanie, A..; (US)
Priority Data:
62/384,776 08.09.2016 US
Title (EN) DEUTERIUM-SUBSTITUTED OXAZEPIN COMPOUNDS
(FR) COMPOSÉS D'OXAZÉPIN À SUBSTITUTION PAR DU DEUTÉRIUM
Abstract: front page image
(EN)Described are deuterium-substituted oxazepin compounds of structural Formula I, which are inhibitors/blockers of the late sodium current. Also described are pharmaceutical compositions comprising the deuterium-substituted oxazepin compounds, and methods of use thereof. (I)
(FR)L'invention concerne des composés d'oxazépin à substitution par du deutérium de formule structurale I, qui sont des inhibiteurs/bloqueurs du courant de sodium tardif. L'invention concerne également des compositions pharmaceutiques comprenant les composés d'oxazépin à substitution par du deutérium, et leurs méthodes d'utilisation. (I)
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)