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1. (WO2018048958) PACLITAXEL-ALBUMIN-BINDING AGENT COMPOSITIONS AND METHODS FOR USING AND MAKING THE SAME

Pub. No.:    WO/2018/048958    International Application No.:    PCT/US2017/050355
Publication Date: Fri Mar 16 00:59:59 CET 2018 International Filing Date: Thu Sep 07 01:59:59 CEST 2017
IPC: A61K 47/64
A61K 47/54
A61P 35/00
Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: MARKOVIC, Svetomir N.
NEVALA, Wendy K.
Title: PACLITAXEL-ALBUMIN-BINDING AGENT COMPOSITIONS AND METHODS FOR USING AND MAKING THE SAME
Abstract:
Described herein are nanoparticle compositions comprising binding agents, carrier proteins and an amount of paclitaxel derivative, and optionally a therapeutic agent. Also described herein are nanoparticle compositions comprising carrier proteins and an amount of paclitaxel, and optionally binding agents and/or a therapeutic agent, wherein the paclitaxel is present in an amount that is less than an amount that provides a therapeutic effect. Also disclosed herein are nanoparticles which contain (a) carrier protein, (b) a paclitaxel derivative, the paclitaxel derivative having reduced toxicity compared to paclitaxel, and optionally (c) a binding agent and/or (d) a therapeutic agent. Also described are methods of making and using the same, in particular, as a cancer therapeutic.