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1. (WO2018048953) ALLOSTERIC CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (CRFR1) ANTAGONISTS THAT DECREASE P-TAU AND IMPROVE COGNITION

Pub. No.:    WO/2018/048953    International Application No.:    PCT/US2017/050347
Publication Date: Fri Mar 16 00:59:59 CET 2018 International Filing Date: Thu Sep 07 01:59:59 CEST 2017
IPC: C07D 409/04
A61K 31/5377
A61K 31/519
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: ALAM, Mohammad Parvez
JOHN, Varghese
Jagodzinska, Barbara
Title: ALLOSTERIC CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (CRFR1) ANTAGONISTS THAT DECREASE P-TAU AND IMPROVE COGNITION
Abstract:
In various embodiments novel allosteric antagonists of the CRFR1 receptor are provided. It discovered that allosteric CRFR1 receptor antagonists are effective to modulate p-Tau levels in Alzheimer's disease (AD) models.