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1. (WO2018048936) METHODS OF DETECTING PER CELL PD-L1 EXPRESSION AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/048936 International Application No.: PCT/US2017/050322
Publication Date: 15.03.2018 International Filing Date: 06.09.2017
IPC:
G01N 1/30 (2006.01) ,G01N 33/483 (2006.01) ,G01N 33/574 (2006.01) ,G01N 15/14 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1
Sampling; Preparing specimens for investigation
28
Preparing specimens for investigation
30
Staining; Impregnating
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10
Investigating individual particles
14
Electro-optical investigation
Applicants: PATTERSON, Bruce K.[US/US]; US
CHARGIN, Amanda Noel[US/US]; US
SHULTS, Keith[US/US]; US
INCELLDX, INC.[US/US]; 1700 El Camino Real Menlo Park, California 94027, US
Inventors: PATTERSON, Bruce K.; US
CHARGIN, Amanda Noel; US
SHULTS, Keith; US
Agent: FIELD, Bret E.; US
Priority Data:
62/384,03706.09.2016US
Title (EN) METHODS OF DETECTING PER CELL PD-L1 EXPRESSION AND USES THEREOF
(FR) PROCÉDÉ DE DÉTECTION DE L'EXPRESSION DE PD-L1 PAR CELLULE ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) Methods are provided for detecting the per cell programmed-death ligand 1 (PD-L1) expression of neoplasia cells. Aspects of the methods include cytometrically assaying a labeled cell suspension to quantify per cell PD-L1 expression to detect whether a neoplastic cell that expresses PD-L1 above a predetermined threshold is present in the neoplasia sample. In addition, kits that find use in practicing the subject methods are also provided.
(FR) L'invention concerne des procédés de détection de l'expression du ligand de mort programmée 1 (PD-L1) par cellule de cellules néoplasiques. Des aspects des procédés comprennent le dosage cytométrique d'une suspension de cellules marquées pour quantifier l'expression PD-L1 par cellule afin de détecter si une cellule néoplasique qui exprime PD-L1 au-dessus d'un seuil prédéterminé est présente dans l'échantillon de néoplasie. L'invention concerne également des kits utilisables dans la mise en œuvre des procédés de l'invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)