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1. (WO2018048762) INDAZOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS

Pub. No.:    WO/2018/048762    International Application No.:    PCT/US2017/050003
Publication Date: Fri Mar 16 00:59:59 CET 2018 International Filing Date: Wed Sep 06 01:59:59 CEST 2017
IPC: C07D 405/14
C07D 231/56
C07D 401/04
C07D 401/06
C07D 409/04
A61K 31/416
A61P 3/10
Applicants: JANSSEN PHARMACEUTICA NV
GAUL, Micheal
Inventors: GAUL, Micheal
XU, Guozhang
YANG, Shyh-Ming
LU, Tianbao
ZHANG, Rui
SONG, Fengbin
Title: INDAZOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS
Abstract:
The present invention is directed to indazole derivatives of formula (I), pharmaceutical compositions containing them and their use in the treatment and / or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.