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1. (WO2018048609) METHOD OF REGULATING IMMUNITY IN THE INTESTINES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/048609    International Application No.:    PCT/US2017/047783
Publication Date: 15.03.2018 International Filing Date: 21.08.2017
IPC:
A61K 31/19 (2006.01), A61K 31/70 (2006.01), A61K 38/31 (2006.01), A61K 38/26 (2006.01)
Applicants: MONELL CHEMICAL SENSES CENTER [US/US]; 3500 Market Street Philadelphia, PA 19104 (US)
Inventors: JIANG, Peihua; (US).
LEI, Weiwei; (US)
Agent: BAK, Mary, E.; (US).
KODROFF, Cathy, A.; (US).
BAK, William; (US).
KITA, Stanley, B.; (US).
DUMINIAK, Robert, J.; (US)
Priority Data:
62/383,662 06.09.2016 US
Title (EN) METHOD OF REGULATING IMMUNITY IN THE INTESTINES
(FR) PROCÉDÉ DE RÉGULATION DE L'IMMUNITÉ DANS LES INTESTINS
Abstract: front page image
(EN)Methods for stimulating the G protein receptor (Gpr91 ) pathway in intestinal cells to release IL-25 and enhance a type II immune response in the subject are useful in the treatment or prevention of bacterial or parasitic infection. Similarly methods and compositions used therein to inhibit or stimulate GPR91 are useful for the treatment or inhibition of certain diseases, such asirritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and Crohn's disease.
(FR)Des procédés de stimulation du récepteur 91 couplé à la protéine G (Gpr91) dans des cellules intestinales pour libérer l'IL-25 et améliorer une réponse immunitaire de type II chez le sujet sont utiles dans le traitement ou la prévention d'une infection bactérienne ou parasitaire. De même, des procédés et des compositions utilisés dans celui-ci pour inhiber ou stimuler le GPR91 sont utiles pour le traitement ou l'inhibition de certaines maladies, telles que le syndrome de l'intestin irritable (IBS), la maladie inflammatoire de l'intestin (IBS) et la maladie de Crohn.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)