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1. (WO2018047894) ANTIBODY FOR TREATING AUTOIMMUNE DISEASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/047894 International Application No.: PCT/JP2017/032212
Publication Date: 15.03.2018 International Filing Date: 07.09.2017
IPC:
C12N 15/09 (2006.01) ,A61K 31/56 (2006.01) ,A61K 39/395 (2006.01) ,A61K 45/00 (2006.01) ,A61P 1/04 (2006.01) ,A61P 3/10 (2006.01) ,A61P 5/16 (2006.01) ,A61P 7/04 (2006.01) ,A61P 7/06 (2006.01) ,A61P 17/00 (2006.01) ,A61P 17/06 (2006.01) ,A61P 19/02 (2006.01) ,A61P 21/00 (2006.01) ,A61P 21/04 (2006.01) ,A61P 25/00 (2006.01) ,A61P 27/02 (2006.01) ,A61P 29/00 (2006.01) ,A61P 31/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/02 (2006.01) ,A61P 37/06 (2006.01) ,A61P 37/08 (2006.01) ,A61P 43/00 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/46 (2006.01) ,C12N 1/15 (2006.01) ,C12N 1/19 (2006.01) ,C12N 1/21 (2006.01) ,C12N 5/10 (2006.01) ,C12P 21/08 (2006.01)
Applicants: DAIICHI SANKYO COMPANY,LIMITED[JP/JP]; 3-5-1,Nihonbashi Honcho,Chuo-ku, Tokyo 1038426, JP
Inventors: MUKASA, Ryuta; JP
NAKAMURA, Kensuke; JP
MURAMATSU, Sumie; JP
MAKITA, Naoyuki; JP
Agent: ISHIBASHI, Koki; JP
TAKEMOTO, Toshiyasu; JP
Priority Data:
2016-17549108.09.2016JP
Title (EN) ANTIBODY FOR TREATING AUTOIMMUNE DISEASE
(FR) ANTICORPS POUR LE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE
(JA) 自己免疫疾患治療用抗体
Abstract:
(EN) Provided is a novel antibody. According to the present invention, a monoclonal antibody or a binding fragment thereof binds to domain 3 of a human LAG-3, and has the properties described in (i) and (vi) and one or more of the properties described in (ii) to (v) below: (i) the antibody has in vitro ADCC activity; (ii) the antibody is a low-fucose antibody and reduces the number of LAG-3 positive cells in vivo; (iii) the antibody is a low-fucose antibody and suppresses experimental autoimmune encephalomyelitis in vivo; (iv) the human LAG-3 binds to a human activated T cell; (v) the human LAG-3 binds to a human major histocompatibility gene complex class II molecule in the presence of the antibody or a binding fragment thereof; and (vi) the human LAG-3 exhibits a human T cell suppression function in the presence of the antibody or a binding fragment thereof.
(FR) L'invention concerne un nouvel anticorps. Selon la présente invention, un anticorps monoclonal ou un fragment de liaison de celui-ci se lie au domaine 3 d'un LAG-3 humain, et a les propriétés décrites dans (i) et (vi) et une ou plusieurs des propriétés décrites dans (ii) à (v) ci-dessous : (i) l'anticorps a une activité ADCC in vitro; (ii) l'anticorps est un anticorps à faible taux de fucose et réduit le nombre de cellules positives à LAG-3 in vivo; (iii) l'anticorps est un anticorps à faible taux de fucose et supprime l'encéphalomyélite auto-immune expérimentale in vivo; (iv) le LAG-3 humain se lie à une cellule T humaine activée; (v) le LAG-3 humain se lie à une molécule de classe II du complexe majeure d'histocompatibilité en présence de l'anticorps ou d'un fragment de liaison de celui-ci; et (vi) le LAG-3 humain présente une fonction de suppression des lymphocytes T humains en présence de l'anticorps ou d'un fragment de liaison de celui-ci.
(JA) 新規抗体を提供すること ヒトLAG-3のドメイン3に結合し、下記(ii)乃至(v)記載の性質のうち1つ以上、並びに、(i)及び(vi)記載の性質を有する、モノクローナル抗体又はその結合断片: (i)イン・ビトロADCC活性を有する; (ii)低フコース形態で、イン・ビボでLAG-3陽性細胞数を低減させる; (iii)低フコース形態で、イン・ビボで実験的自己免疫性脳脊髄炎を抑制する; (iv)ヒト活性化T細胞に結合する; (v)該抗体又はその結合断片存在下で、ヒトLAG-3とヒト主要組織適合遺伝子複合体クラスII分子は結合する;及び (vi)該抗体又はその結合断片存在下で、ヒトLAG-3はヒトT細胞抑制機能を奏する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)