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1. (WO2018046870) BIOMATERIAL FOR THERAPEUTIC USE
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Pub. No.: WO/2018/046870 International Application No.: PCT/FR2017/052395
Publication Date: 15.03.2018 International Filing Date: 08.09.2017
IPC:
A61L 27/36 (2006.01) ,A61L 27/44 (2006.01) ,A61L 27/58 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
40
Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
44
having a macromolecular matrix
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
58
Materials at least partially resorbable by the body
Applicants:
ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS (AP-HP) [FR/FR]; 3, Avenue Victoria 75184 Cedex04 PARIS, FR
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101 rue de Tolbiac 75013 PARIS, FR
UNIVERSITE RENE DESCARTES - PARIS 5 [FR/FR]; 12, rue de l'Ecole de Médecine 75006 PARIS, FR
Inventors:
MENASCHE, Philippe; FR
RENAULT, Nisa; FR
BELLAMY, Valérie; FR
PIDIAL, Laetitia; FR
Agent:
NOVAGRAAF TECHNOLOGIES; 2 rue Sarah Bernhardt CS90017 92665 ASNIÈRES-SUR-SEINE CEDEX, FR
Priority Data:
165841609.09.2016FR
Title (EN) BIOMATERIAL FOR THERAPEUTIC USE
(FR) BIOMATERIAU A USAGE THERAPEUTIQUE
Abstract:
(EN) The present invention relates to a biomaterial for use as medicament intended for the treatment of cardiac tissues, to a process for producing the biomaterial, and also to a biomaterial according to the invention for use as medicament or medical device. The biomaterial of the present invention comprises a biocompatible biodegradable polymer including extracellular vesicles from stem cells. The process of the present invention comprises a step of soaking the biocompatible biodegradable polymer in a biocompatible liquid medium comprising extracellular vesicles from stem cells or from the differentiated derivatives thereof, or a mixing of the biocompatible biodegradable polymer or of the corresponding monomer(s) with extracellular vesicles from stem cells. The biomaterial according to the invention is of use as medicament, especially for the treatment of deficient human or animal cardiac tissue. Figure 7
(FR) Abrégé La présente invention se rapporte à un biomatériaupour une utilisation comme médicament destiné au traitement d'un tissu cardiaque, à un procédé de fabrication du biomatériau, ainsi qu'à un biomatériau selon l'invention pour une utilisation comme médicament ou dispositif médical. Le biomatériau de la présente invention comprendun polymère biocompatible biodégradable incluant des vésicules extracellulaires de cellules souches. Le procédé de la présente invention comprend une étape de trempage du polymère biocompatible biodégradable dans un milieu liquide biocompatible comprenant des vésicules extracellulaires de cellules souches ou de leurs dérivés différenciés ou un mélange du polymère biocompatible biodégradable ou du ou des monomères correspondants avec des vésicules extracellulaires de cellules souches. Le biomatériau selon l'invention est utile comme médicament, notamment pour le traitement d'un tissu cardiaque déficient humain ou animal. Figure 7
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)