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1. (WO2018046772) ACID-ALPHA GLUCOSIDASE VARIANTS AND USES THEREOF

Pub. No.:    WO/2018/046772    International Application No.:    PCT/EP2017/072942
Publication Date: Fri Mar 16 00:59:59 CET 2018 International Filing Date: Wed Sep 13 01:59:59 CEST 2017
IPC: C12N 9/26
Applicants: GENETHON
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
DUKE UNIVERSITY
Inventors: MINGOZZI, Federico
RONZITTI, Giuseppe
KOEBERL, Dwight D.
HAN, Sang-Oh
Title: ACID-ALPHA GLUCOSIDASE VARIANTS AND USES THEREOF
Abstract:
The present invention relates to variants of acid-alpha glucosidase and uses thereof. Said variants are sequence-optimized and/or are linked to a heterogenous signal peptide.