WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018046525) HC-CDR3-ONLY LIBRARIES WITH REDUCED COMBINATORIAL REDUNDANCY AND OPTIMIZED LOOP LENGTH DISTRIBUTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/046525    International Application No.:    PCT/EP2017/072315
Publication Date: 15.03.2018 International Filing Date: 06.09.2017
IPC:
C40B 40/08 (2006.01), C40B 40/10 (2006.01), C07K 16/00 (2006.01), C12N 15/00 (2006.01)
Applicants: ITALFARMACO S.P.A. [IT/IT]; Viale Fulvio Testi, 330 I-20126 Milano (IT)
Inventors: LAHM, Armin; (IT).
STEINKÜHLER, Christian; (IT)
Agent: PISTOLESI, Roberto; (IT).
DRAGOTTI, Gianfranco; (IT).
FINETTI, Claudia; (IT).
VIGANÒ, Elena; (IT).
LAMPIS, Marco; (IT).
BOGGIO MERLO, Anita; (IT).
MARRI, Luca; (IT)
Priority Data:
16187884.8 08.09.2016 EP
Title (EN) HC-CDR3-ONLY LIBRARIES WITH REDUCED COMBINATORIAL REDUNDANCY AND OPTIMIZED LOOP LENGTH DISTRIBUTION
(FR) BANQUES DE HC-CDR3-UNIQUEMENT À REDONDANCE COMBINATOIRE RÉDUITE ET DISTRIBUTION DE LONGUEUR DE BOUCLE OPTIMISÉE
Abstract: front page image
(EN)The present invention provides for a library of vectors comprising human HC-CDR3 regions of varying length, wherein the diversity of said library is focused on the HC-CDR3 region only and diversity has been optimized such that redundancy is reduced for short HC-CDR3 loops and coverage of HC-CDR3 region variants for longer loop lengths has been increased. The library of the present invention is displayed on phage for selection against target antigens.
(FR)La présente invention concerne une banque de vecteurs comprenant des régions HC-CDR3 humaines de longueur variable, la diversité de ladite banque étant focalisée sur la région HC-CDR3 uniquement et la diversité ayant été optimisée de telle sorte que la redondance est réduite pour les boucles HC-CDR3 courtes et que la couverture des variants de la région HC-CDR3 pour des longueurs de boucle plus longues a été augmentée. La banque de la présente invention est exprimée sur phage pour une sélection contre des antigènes cibles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)