Search International and National Patent Collections
|1. (WO2018045957) CDK4/6 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF|
|Applicants:||JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.
SHANGHAI HANSOH BIOMEDICAL CO., LTD.
|Title:||CDK4/6 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF|
The present invention relates to a CDK4/6 inhibitor having the structure of formula (I), a preparation method therefor and an application thereof. The series of compounds in formula (I) which are developed in the present invention has strong inhibitory effects on CDK4/6 kinase activities. Said compounds can be widely used in the preparation of a medicament for preventing and/or treating cancer or tumor-related diseases, especially diseases such as bladder cancer, ovarian cancer, peritoneal cancer, pancreatic cancer, breast cancer, uterine cancer, cervical cancer, endometrial cancer, prostate cancer, female reproductive tract cancer, testicular cancer, gastrointestinal stromal tumors and prostate tumors. The present invention is well positioned to be developed into a new generation of CDK4/6 inhibitor drugs.