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1. (WO2018045957) CDK4/6 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Pub. No.:    WO/2018/045957    International Application No.:    PCT/CN2017/100679
Publication Date: Fri Mar 16 00:59:59 CET 2018 International Filing Date: Thu Sep 07 01:59:59 CEST 2017
IPC: C07D 401/14
A61K 31/517
A61P 35/00
Applicants: JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.
江苏豪森药业集团有限公司
SHANGHAI HANSOH BIOMEDICAL CO., LTD.
上海翰森生物医药科技有限公司
Inventors: LIU, Shiqiang
刘世强
ZHOU, Yuanfeng
周远峰
WU, Xuesong
吴雪松
BAO, Rudi
包如迪
Title: CDK4/6 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Abstract:
The present invention relates to a CDK4/6 inhibitor having the structure of formula (I), a preparation method therefor and an application thereof. The series of compounds in formula (I) which are developed in the present invention has strong inhibitory effects on CDK4/6 kinase activities. Said compounds can be widely used in the preparation of a medicament for preventing and/or treating cancer or tumor-related diseases, especially diseases such as bladder cancer, ovarian cancer, peritoneal cancer, pancreatic cancer, breast cancer, uterine cancer, cervical cancer, endometrial cancer, prostate cancer, female reproductive tract cancer, testicular cancer, gastrointestinal stromal tumors and prostate tumors. The present invention is well positioned to be developed into a new generation of CDK4/6 inhibitor drugs.