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1. (WO2018045956) BENZIMIDAZOLE COMPOUND KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Pub. No.:    WO/2018/045956    International Application No.:    PCT/CN2017/100678
Publication Date: Fri Mar 16 00:59:59 CET 2018 International Filing Date: Thu Sep 07 01:59:59 CEST 2017
IPC: C07D 401/14
A61K 31/4184
A61P 35/00
A61P 35/04
Applicants: JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.
江苏豪森药业集团有限公司
SHANGHAI HANSOH BIOMEDICAL CO., LTD.
上海翰森生物医药科技有限公司
Inventors: LIU, Shiqiang
刘世强
ZHOU, Yuanfeng
周远峰
WU, Xuesong
吴雪松
BAO, Rudi
包如迪
Title: BENZIMIDAZOLE COMPOUND KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Abstract:
Provided is a compound of general formula (I), a method for preparing the same, and a pharmaceutical composition containing the same, as well as the use thereof as a benzimidazole kinase inhibitor in the preparation of a medicament for preventing and/or treating cancer or tumor-related diseases, especially diseases such as bladder cancer, ovarian cancer, peritoneal cancer, pancreatic cancer, breast cancer, uterine cancer, cervical cancer, endometrial cancer, prostate cancer, female reproductive tract cancer, testicular cancer, gastrointestinal stromal tumors and prostate tumors.