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1. (WO2018045464) BIFUNCTIONAL ALPHA-SYNUCLEIN BINDING AGENTS AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/045464 International Application No.: PCT/CA2017/051053
Publication Date: 15.03.2018 International Filing Date: 08.09.2017
IPC:
C07D 473/06 (2006.01) ,A61K 47/55 (2017.01) ,A61K 49/00 (2006.01) ,A61K 51/04 (2006.01) ,A61P 25/16 (2006.01)
Applicants: UNIVERSITY OF SASKATCHEWAN[CA/CA]; Industry Liaison Office Suite 250 - 15 Innovation Boulevard Saskatoon, Saskatchewan S7N 2X8, CA
Inventors: KAKISH, Joseph; CA
KROL, Edward; CA
LEE, Jeremy; CA
ALLEN, Kevin; CA
Agent: MARLES, Jennifer A.; CA
GREEN, Bruce M.; CA
MCGRUDER, David J.; CA
BAILEY, Thomas W.; CA
MANNING, Gavin N.; CA
KONDOR, George F.; CA
ASH, Craig A.; CA
SUE, Hilton W.C.; CA
RATTRAY, Todd A.; CA
FONG, Amy M.; CA
TAKAGAWA, David H.; CA
MELNYCHUK, Stephanie A.; CA
JONES, Roni M.; CA
Priority Data:
62/385,16808.09.2016US
Title (EN) BIFUNCTIONAL ALPHA-SYNUCLEIN BINDING AGENTS AND USES THEREOF
(FR) AGENTS DE LIAISON ALPHA-SYNUCLÉINE ET LEURS UTILISATIONS
Abstract: front page image
(EN) Bifunctional molecules having first and second alpha-synuclein binding agents coupled by a linker are disclosed. The bifunctional molecules have potential utility in the diagnosis, treatment and/or prophylaxis of disorders in which alpha-synuclein is implicated, including Parkinson's disease. Methods of making and using the bifunctional molecules are disclosed.
(FR) L'invention concerne des molécules bifonctionnelles ayant des premier et second agents de liaison alpha-synucléine couplés par un lieur. Les molécules bifonctionnelles ont une utilité potentielle dans le diagnostic, le traitement et/ou la prophylaxie de troubles dans lesquels l'alpha-synucléine est impliquée, y compris la maladie de Parkinson. L'invention concerne des procédés de fabrication et d'utilisation des molécules bifonctionnelles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)