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1. (WO2018045344) METHODS FOR PRODUCING VIRUS FOR VACCINE PRODUCTION
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Pub. No.: WO/2018/045344 International Application No.: PCT/US2017/049956
Publication Date: 08.03.2018 International Filing Date: 01.09.2017
IPC:
A61K 39/125 (2006.01) ,A61K 39/13 (2006.01) ,C07K 14/085 (2006.01) ,C07K 14/105 (2006.01) ,C12N 7/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
125
Picornaviridae, e.g. calicivirus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
125
Picornaviridae, e.g. calicivirus
13
Poliovirus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
085
Picornaviridae, e.g. coxsackie virus, echovirus, enterovirus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
085
Picornaviridae, e.g. coxsackie virus, echovirus, enterovirus
105
Poliovirus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
02
Recovery or purification
Applicants:
TAKEDA VACCINES, INC. [US/US]; 75 Sydney Street Cambridge, MA 02139, US
TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 1-1, Doshomachi 4-Chome Chuo-ku, Osaka-shi Osaka, 541-0045, JP
Inventors:
RAO, Raman; SG
SATO, Tatsuki; JP
ODA, Kaori; JP
NAKAMURA, Kuniaki; JP
NISHIHAMA, Takeshi; JP
Agent:
LITTLEFIELD, Otis; US
AHN, Sejin; US
AIKEN, Charity; US
ARJOMAND, Mehran; US
BANKO, Max; US
Priority Data:
62/382,62101.09.2016US
Title (EN) METHODS FOR PRODUCING VIRUS FOR VACCINE PRODUCTION
(FR) PROCÉDÉS DE PRODUCTION DE VIRUS POUR PRODUIRE DES VACCINS
Abstract:
(EN) The present disclosure relates to methods of producing Enterovirus C, e.g., for poliomyelitis vaccine production. In some embodiments, the methods include adding polysorbate to the cell culture medium during or prior to inoculation with the virus and/or culturing cells in a fixed bed bioreactor. Further provided herein is an Enterovirus C produced by the methods of production disclosed herein, as well as compositions, immunogenic compositions, and vaccines related thereto.
(FR) La présente invention concerne des procédés de production d'entérovirus C, par exemple pour la production de vaccins contre la poliomyélite. Dans certains modes de réalisation, les procédés comprennent l'ajout de polysorbate au milieu de culture cellulaire pendant ou avant l'inoculation du virus et/ou la culture des cellules dans un bioréacteur à lit fixe. L'invention concerne également un entérovirus C produit par les procédés de production de l'invention, ainsi que des compositions, des compositions immunogènes et des vaccins associés à ce dernier.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)